Laboratory of Neurophysics and Neurophysiology神经物理学与神经生理学实验室

The Laboratory of Neurophysics and Neurophysiology (LNP2) was established in 2007 within the School of Life Sciences at the University of Science and Technology of China and the Hefei National Research Center for Physical Sciences at the Microscale. The laboratory is led by Professors Guoqiang Bi and Pak-Ming Lau. Our research focuses on advancing nanoscale imaging technologies—including cryo-electron tomography (cryo-ET), correlative light and electron microscopy (CLEM), and super-resolution microscopy — and applying them to investigate the fine structure and function of neuronal synapses, the mechanisms of synaptic plasticity, and the organization and function of brain-wide connectivity at the mesoscale.

In recent years, we have independently developed VISoR, a state-of-the-art fluorescence microscopy platform for high-speed, three-dimensional imaging of large biological specimens. Drawing on advances across the life sciences, physics, chemistry, and computer science, VISoR enables centimeter-scale imaging of biological samples at micrometer resolution. We are using this technology to map multimodal structural and functional brain connectivity across spatial and temporal scales in rodents, including mice and rats, and in nonhuman primates such as macaques. Through this work, we seek to enable new advances in neuroscience, the study of brain disorders, and artificial intelligence.

We welcome talented and highly motivated researchers to join our laboratory. Our goal is to train a new generation of interdisciplinary scientists who are proficient in cutting-edge research methods and technologies and who bring broad perspectives, intellectual curiosity, and creativity to their work.

神经物理学与神经生理学实验室（LNP2），依托于中国科大生命科学学院和合肥微尺度物质科学国家研究中心，始建于2007年，负责人是毕国强教授与刘北明教授。主要致力于利用冷冻电子断层成像（cryoET）、光电关联显微、超分辨显微成像等纳米成像手段在技术和应用上取得突破，并将这一系列国际前沿技术用于解析神经突触的精细结构和功能，神经突触可塑性机制以及大脑介观尺度下的环路联结图谱的结构和功能。

近几年来，自主研发大样品三维高速同步飞扫显微技术（VISoR），是结合了生命科学、物理学、化学、计算机科学等多学科的，以微米分辨率在厘米尺度上研究生物大样品的荧光显微技术。VISoR技术致力于解析大小鼠等啮齿类和猕猴等灵长类动物的各时间和空间尺度上多模块的脑连接和功能连接图谱，并在此基础上对神经科学、脑疾病、人工智能等领域取得突破。

实验室欢迎有志和有识之士加入，并培养掌握前沿科学研究方法与尖端技术、视野广阔、富于创造力的新一代跨学科精英人才。